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컴퓨터 제어에 의한 빵 효모의 유가배양

Computer-aided Fed-bath Culture of Baker's Yeast

박홍우 최차용

Park HW Choi CY

HWAHAK KONGHAK, December 1981, 19(6), 419-430(12)
https://doi.org/NONE

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Abstract

PDP 11-03 마이크로 컴퓨터를 발효 시스템에 성공적으로 연결하고 개스 분석기를 주된 측정 기기로 사용하여 효모 Saccharomyces cerevisiae의 배양을 수행하였다. 필요한 방정식과 컴퓨터 프로그램을 개발하여 시스템 운전에 사용하였다.
최적 휘드 백 정책을 컴퓨터 프로그램하여 컴퓨터에 기억시킨 후 측정치를 사용하여 적정한 값의 제어시그날을 발생시키도록 하였다.
간접적으로 얻은 균체농도는 직접 측정치를 상당히 정확하게 예측하였다. 온 라인 휘드 백 제어를 수행한 결과 얻어진 호흡지수는 아주 흡족한 상태를 보였으며 전반적인 세포 생산 수율은 회분 배양과 비교했을 때 상당히 증가되었다.

A PDP 11-03 microcomputer was successfully interfaced to the fermentation system and yeast Saccharomyces cerevisiae cultivation with this computerized system was carried out using the gas analyzers as the primary measuring elements. The necessary equations and computer programs were developed and used in the system operation. The optimal feed-back control policy computerized and stored in the system utilizes these monitored variables in order to generate the output control signals at proper level. The indirectly determined cell-concentration has predicted the direct measurement rather accurately. The profile of the respiratory quotient obtained upon exercising the on-line fed-back control has shown a very smooth and desirable behaviour and the oberall cell yield has been improved quite significantly as compared with the batch system without control.

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