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항동맥경화 활성 바이오소재 개발 연구 동향 및 활용 전망

Current Status and Application Prospects of Anti-Atherosclerotic Active Biomaterials

김승희1 이정호1 유하영1†
1상명대학교 생명공학과
In Press, Journal Pre-proof, Available online 1 May 2024


전세계적으로 발병 및 사망률이 높은 동맥경화증은 뇌졸중, 심근경색 등 심혈관질환의 주요 병증의 원인인 만성 염증성 질환이다. 동맥경화증은 지질 침착에 의한 죽종(atheroma) 형성이 주요한 특징이며, 이로 인해 혈전증이 유발된다. 현재, 합성 치료제의 부작용 우려로 인해 생물 유래 항동맥경화 소재 개발의 필요성이 강조되고 있다. 이에 따라 동맥경화증의 개선 및 치료를 위한 바이오소재의 발굴 및 기전 규명 등 관련 연구가 활발히 수행되고 있다. 본고에서는 동맥경화증의 발병 기전을 살펴보고, 항동맥경화증 활성이 보고된 바이오소재의 연구 동향 및 활용 전망을 제시하고자 한다.
Atherosclerosis, a disease with high morbidity and mortality worldwide, is a chronic inflammatory disease that is a major cause of cardiovascular diseases such as stroke and myocardial infarction. Atherosclerosis is characterized by the accumulation of lipid deposits in the arteries, forming atheromas. This leads to the narrowing of the arteries and thrombosis. Recently, the need to develop bio-derived anti-atherosclerotic materials has been highlighted with concerns about the side effects of synthetic therapeutics, and related research (such as the discovery of biomaterials for the improvement and treatment of atherosclerosis and the identification of mechanisms) has been actively conducted. In this review, the pathogenesis of atherosclerosis was investigated, and the current status and application prospects of biomaterials with anti-atherosclerotic activity were proposed.

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