The modified Kent-Eisenberg model was used to predict the solubility of carbon dioxide in aqueous 2-amino-2-methyl-1,3-propanediol (AMPO) solutions over a wide range of solvent concentration (10-30 mass %), temperature of (30-60℃), and partial pressure of carbon dioxide (5-1,100 kPa). For more accurate prediction, a new set of experimental data of this system was also presented and used in model calculation. The predicted results by the modified Kent-Eisenberg model were found to be in good agreement with the experimental data. The equilibrium constant, K₁, which represented the deprotonation reaction of AMPD, was expressed as a function of not only temperature but also loading capacity and amine concentration.