Adsorption of cephalosporin C on a non-ionic polymeric sorbent, SP850, was studied in a column adsorber under various operating conditions such as temperature, pH, concentration, flow rate, and L/D ratio. An adsorption model was formulated by employing the surface diffusion inside resin particles. Single-species equilibrium data were simply represented by Freundlich equation. The model equations were solved numerically by an orthogonal collocation method. The model successfully simulates the adsorption behavior in a column under different operating conditions, but the considerable deviations are observed at low solution pHs, at which different ionic species may coexist.
Dechow FJ, "Sparation and Purification Techniques in Biotechnology," Noyes, Park Ridge, NJ, 1989
Elander RP, Aoki H, "β-Lactam-Producing Microorganism: Their Biology and Fermentation Behavior, in Chemistry and Biology of β-Lactam Antibiotics," Academic Press, 3, 83, 1982
Lee JW, Park HC, Moon H, Sep. Purif. Technol., in press, 1997
Moon H, Lee WK, J. Colloid Interface Sci., 961, 162, 1983