Effects of various additives, such as diatomaceous earth, inorganic adsorbent, and polymeric flocculant, on cake filtration performance were evaluated. By performing the standard vacuum filtration experiments under a constant pressure condition, we quantified their ability to reduce cake compressibility and to remove fine particulate matters. From the flux decline curves obtained, we used modified Ruth equation to determine the cake compressibility index. The filtrate clarity was quantified by measuring its turbidity spectrophotometrically. Diatomaceous earth filter aid was very effective in reducing the compressibility thereby improving filtrate flux. Calcium phosphate adsorbent was more effective in clarity improvement than in flux enhancement, whereas an anionic flocculant was effective in both aspects. When these additives were used together, the expected additive, synergic effect was not realized. However, about 3.5 times higher initial flux and 6-fold improved clarity were obtained as compared to the control experiment. Experimentally obtained flux decline curves were perfectly fitted into one of the Hermia’s blocking filtration law equations. Also, it was experimentally observed that the compressibility reduction improved filtrate clarity in a linear fashion. This type of approach is useful to quantitatively determine each additive’s characteristics and thus to maximize the performance of cake filtration operations.