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Issue
Korean Journal of Chemical Engineering,
Vol.11, No.4, 282-289, 1994
A MATHEMATICAL MODEL FOR THE REGULATION OF TRYPTOPHAH PROMOTER
Park TH
Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3β-indoles-crylic acid(IAA). A mathematical model is proposed for the regulation of the promoter by the manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a plateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree behaviors agree with the previous experimental investigation.
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[Cited By]
  1. Kim SG, Bae YC, Ryu SO, Korean Journal of Chemical Engineering, 17(6), 638, 2000
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