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Issue
Korean Journal of Chemical Engineering,
Vol.25, No.6, 1444-1447, 2008
CMC and dynamic properties of poly(VA-b-St) copolymer micelles for drug delivery
Li GH, Cho CG
The polymeric micelles from amphiphilic block copolymer poly(vinyl alcohol-b-styrene) (poly(VA-b-St)) with different syndiotacticity of poly(vinyl alcohol) (PVA) block were prepared by dialysis against water. Critical micelle concentration (CMC) and dynamic properties of poly(VA-b-St) copolymeric micelles were investigated by fluorescence techniques. From the fluorescence emission spectrum measurements using pyrene as a fluorescence probe, the observed CMC value was in the range of 0.125-4.47 mg/L. The CMC value increased with decreasing the weight ratio of PS to PVA block and with increasing the syndiotacticity of PVA block. The rate of pyrene release was very slow for block copolymers containing PVA block with higher syndiotacticity, which indicates that their micelles have increased kinetic stability.
Keywords: Poly(VA-b-St); Syndiotacticity; Micelle; Critical Micelle Concentration; Kinetic Stability
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[Cited By]
  1. Rub MA, Azum N, Khan F, Sehemi GA, Asiri AM, Korean Journal of Chemical Engineering, 32(10), 2142, 2015
  2. Lee YC, Kang IJ, Korean Chemical Engineering Research, 54(2), 200, 2016
  3. Alfaifi SYM, Kumar D, Rub MA, Khan F, Azum N, Khan A, Asiri AM, Dzudzevic-Cancar H, Korean Journal of Chemical Engineering, 38(2), 386, 2021
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