To comprehensively assess and understand the environmental impacts of air pollutants emitted from largescale point sources, the complex, non-linear photochemistry inside the plumes should be considered together with atmospheric turbulent dispersion of the air pollutants. For this purpose, a reactive puff model that can consider both atmospheric turbulent dispersion and photochemical reactions was developed in this study. The model’s performance was evaluated by comparing the model-predicted concentrations with the ship-plume chemical concentrations measured from the Intercontinental Transport and Chemical Transformation (ITCT) 2K2 field campaign. This comparison study confirmed the ability of the developed reactive puff model to capture the major characteristics of both plume dispersion and photochemical reactions. Based on these findings, the reactive puff model was applied to a Korean power plant (Hadong) as a case study.