The heat transfer effect of an inert gas on a multi-tubular reactor for a partial oxidation reaction has been determined. The model reaction system in the study was partial oxidation of propylene to acrolein. Both theoretical modeling and experimental studies have been performed to determine the heat transfer effect of inert gas on the system. Among many inert gases, CO2 was selected and tested as a diluent gas for the partial oxidation of propylene to acrolein system instead of conventionally used N2. The productivity increase through changing the inert gas from N2 to CO2 was possible due to the heat transfer capability of CO2. In this study, by replacing the inert gas from N2 to CO2, productivity increased up to 14%.