This study presents a technique for adsorption of paclitaxel on Sylopute using ultrasonic cavitation bubbles and gas bubbles. Compared with the conventional adsorption (control), the adsorbed amount and adsorption rate constant increased, respectively, by 1.27-1.44 times and 7.44-9.71 times in ultrasonic adsorption (with mixing at 80-250W), 1.14-1.27 times and 4.63-9.31 times in ultrasonic adsorption (without mixing at 80-250 W), and 1.06-1.19 times and 1.18-1.34 times in gas bubble-adsorption (without mixing at 1.15-9.41 L/min). As a result of investigating the adsorption mechanism in which cavitation bubbles were introduced, it was shown that microjets and shock waves produced by bubble collapse, rather than the bubble itself, drastically improve mass transport in the pores of the adsorbent, thereby completely eliminating intraparticle diffusion resistance. In the case of gas bubbles, although the intraparticle diffusion coefficient increased by 1.34-1.75 times compared with the control, there was a limitation in promoting intraparticle diffusion.