Issue
Korean Journal of Chemical Engineering,
Vol.38, No.3, 645-651, 2021
Enhancing response time of micro-patterned thermoresponsive hydrogels by incorporation of pores
Micro-patterned hydrogels have received increasing attention in various research fields that need a fine structure and advanced functions compared to bulk hydrogels. For enhancing their performance, control of the size and distribution of pores in hydrogels is crucial. In particular, for the application of thermoresponsive hydrogels to a soft actuator, the characteristics of pores play an important role in enhancing the response time. We formed a porous structure in micro-patterns of polydiethylacrylamide (PDEAM), a thermoresponsive hydrogel, and analyzed the effect of pore size on the response time of the patterned hydrogels. Micro-patterned thermoresponsive hydrogels are fabricated by photo-crosslinking PDEAM copolymerized with benzophenone photo-crosslinker and polystyrene (PS) as a porogen. Pores sufficiently smaller than patterned objects, between a few micrometers to a few tens of micrometers, are successfully formed by controlling the content and molecular weight of PS. As the size and number of pores increase, the response time is improved, and the response time for swelling and deswelling is improved by up to 52 and 43% by blending PDEAM with 50 vol% of low molecular weight PS (5 kg/mol). This simple way to form a sub-millimeter scale hydrogel structure with controlled pores can be utilized in the emerging research fields, including 3D cell scaffolds, targeted drug delivery, and soft robotics.
[References]
  1. Ifkovits JL, Burdick JA, Tissue Eng., 13, 2369, 2007
  2. Pereira RF, Bartolo PJ, Engineering, 1, 90, 2015
  3. Li J, Mooney DJ, Nat. Rev. Mater., 1, 16071, 2016
  4. Jeon SJ, Hauser AW, Hayward RC, Accounts Chem. Res., 50, 161, 2017
  5. van Manen T, Janbaz S, Zadpoor AA, Mater. Today, 21, 144, 2018
  6. Erol O, Pantula A, Liu W, Gracias DH, Adv. Mater. Technol., 4, 190004, 2019
  7. Baker BM, Chen CS, J. Cell Sci., 125, 3015, 2012
  8. Jamal M, Kadam SS, Xiao R, Jivan F, Onn TM, Fernandes R, Nguyen TD, Gracias DH, Adv. Healthcare Mater., 2, 1142, 2013
  9. Shim TS, Kim SH, Heo CJ, Jeon HC, Yang SM, Angew. Chem.-Int. Edit., 51, 1420, 2012
  10. Leong TG, Randall CL, Benson BR, Bassik N, Stern GM, Gracias DH, Proc. Natl. Acad. Sci. U.S.A., 106, 703, 2009
  11. Cianchetti M, Laschi C, Menciassi A, Dario P, Nat. Rev. Mater., 3, 143, 2018
  12. Tanaka T, Fillmore DJ, J. Chem. Phys., 70, 1214, 1970
  13. Shibayama M, Tanaka T, Adv. Polym. Sci., 109, 1, 1993
  14. Zhang XZ, Xu XD, Cheng SX, Zhuo RX, Soft Matter, 4, 385, 2008
  15. Zhang XZ, Yang YY, Chung TS, Ma KX, Langmuir, 17(20), 6094, 2001
  16. Cheng SX, Zhang JT, Zhuo RX, J. Biomed. Mater. Res. A, 67, 96, 2003
  17. Zhang JT, Cheng SX, Zhuo RX, J. Polym. Sci. A: Polym. Chem., 41(15), 2390, 2003
  18. Serizawa T, Wakita K, Akashi M, Macromolecules, 35(1), 10, 2002
  19. Xue W, Champ S, Huglin MB, Jones TG, Eur. Polym. J., 40, 467, 2004
  20. Grenier J, Duval H, Barou F, Lv P, David B, Letourneur D, Acta Biomater., 94, 195, 2019
  21. Savina IN, Ingavle GC, Cundy AB, Mikhalovsky SV, Sci. Rep., 6, 21154, 2016
  22. Antonietti M, Caruso RA, Goltner CG, Weissenberger MC, Macromolecules, 32(5), 1383, 1999
  23. Jiang SH, Liu FY, Lerch A, Ionov L, Agarwal S, Adv. Mater., 27(33), 4865, 2015
  24. Bryant SJ, Cuy JL, Hauch KD, Ratner BD, Biomaterials, 28, 2978, 2007
  25. Wang S, Li L, Su D, Robin K, Brown KA, ACS Appl. Mater. Interfaces, 10, 34604, 2018
  26. Higgins JS, Lipson JEG, White RP, Phil. Trans. R. Soc. A, 368, 1009, 2010
  27. Walheim S, Boltau M, Mlynek J, Krausch G, Steiner U, Macromolecules, 30(17), 4995, 1997
  28. Christensen SK, Chiappelli MC, Hayward RC, Macromolecules, 45(12), 5237, 2012
  29. Jia J, Sarker M, Steinmetz MG, Shukla R, Rathore RJ, J. Org. Chem., 73, 8867, 2008
  30. Kim J, Hanna JA, Byun M, Santangelo CD, Hayward RC, Science, 335(6073), 1201, 2012
  31. Na JH, Evans AA, Bae J, Chiappelli MC, Santangelo CD, Lang RJ, Hull TC, Hayward RC, Adv. Mater., 27(1), 79, 2015
  32. Jeon SJ, Hayward RC, Adv. Mater., 29, 160611, 2017
  33. Jeon SJ, Hayward RC, Soft Matter, 16, 688, 2020
  34. Kojima H, Polym. J., 50, 411, 2018
  35. Bandyopadhyay S, Sharma A, Alvi MAA, Raju R, Glomm WR, RSC Adv., 7, 53192, 2017
  36. Guo H, Cheng J, Wang J, Huang P, Liu Y, Jia Z, Chen X, Sui K, Li T, Nie Z, J. Mater. Chem. B, 5, 2883, 2017
  37. Ziolkowski B, Florea L, Theobald J, Benito-Lopez F, Diamond D, J. Mater. Sci., 51(3), 1392, 2016
  38. Yi J, Choe G, Park J, Lee JY, Polym. J., 52, 823, 2020
  39. Beckett LE, Lewis JT, Tonge TK, Korley LTJ, ACS Biomater. Sci. Eng., 6, 5453, 2020
  40. Dragan ES, Chem. Eng. J., 243, 572, 2014
  41. Gong JP, Soft Matter, 6, 2583, 2010