About The Journal
  Aims and Scope
  Editorial Board
  Submit a Manuscript 
  Subscription Information
  Guidelines for Publication
  Ethics
Articles & Issues
  Search
  Issue
  Online First
  KJChE on
For Authors
  Instructions to Authors
  Ethical Responsibilities of
  Authors in KJChE
  Ethics in Publishing
  Peer Review Process
  Author's Checklist
  Copyright Transfer Form
Contact us
 
 
 
Issue
Korean Journal of Chemical Engineering,
Vol.36, No.5, 780-788, 2019
Aqueous two-phase systems for cephalexin monohydrate partitioning using poly ethylene glycol and sodium tartrate dihydrate:Experimental and thermodynamic modeling
Edrisi S, Bakhshi H, Rahimnejad M
The partitioning of cephalexin monohydrate in aqueous two-phase system (ATPS) of polyethylene glycol (PEG) with different molecular weights (1000, 2000, 6000, and 8000) and sodium tartrate dihydrate salt was investigated. Equilibrium compositions of two liquid phases were obtained in each system. The experimental data were correlated using the extended NRTL and a modified UNIQUAC (UNIQUAC+DH) models by adding a Debye-Huckel term (DH) to original models for taking into account the long range forces term of activity coefficient of components. The results show that the molecular weight of the polymer has a considerable effect on the partition coefficient of cephalexin monohydrate. The comparison of results for presented models with the experimental data demonstrates that the investigated thermodynamic models can correlate the equilibrium composition very well. The extended NRTL model with AARD of 0.099 is superior to UNIQUAC+DH.
Keywords: Cephalexin Monohydrate; Aqueous Two Phase System; Thermodynamic Modeling; Partition Coefficient
[References]
  1. Belter P, Cussler E, Hu W, Elution chromatography-Bioseparation, Downstream Processing for Biotechnology, New York (1988).
  2. Mokhtarani B, Karimzadeh R, Amini MH, Manesh SD, Biochem. Eng. J., 38, 241, 2008
  3. Mistry SL, Kaul A, Merchuk J, Asenjo J, J. Chromatogr. A, 741, 151, 1996
  4. Mistry S, Asenjo J, Zaror C, Bioseparation, 3, 343, 1992
  5. Huenupi E, Gomez A, Andrews BA, Asenjo JA, J. Chem. Technol. Biotechnol., 74(3), 256, 1999
  6. Iqbal M, Tao Y, Xie S, Zhu Y, Chen D, Wang X, Huang L, Peng D, Sattar A, Shabbir MAB, Biol. Proced. Online., 18, 18, 2016
  7. Tada ED, Loh W, Pessoa PD, Fluid Phase Equilib., 218(2), 221, 2004
  8. de Lemos LR, Santos IJB, Rodrigues GD, Ferreira GMD, da Silva MDCH, da Silva MDCH, de Carvalho RMM, J. Chem. Eng. Data, 55, 1193, 2009
  9. Li YL, Huang R, Zhu Q, Yu YH, Hu J, J. Chem. Eng. Data, 62(2), 796, 2017
  10. Li Y, Zhang N, Xu S, Zhu Q, Hu J, J. Dispersion Sci. Technol., 1 (2018).
  11. Yu L, Zhang H, Yang L, Tian K, Protein Expression Purif., 156, 8, 2019
  12. Madadi B, Pazuki G, Nasernejad B, J. Chem. Eng. Data, 58(10), 2785, 2013
  13. Wang F, Chen T, Shang Y, Liu H, Korean J. Chem. Eng., 28(3), 923, 2011
  14. Zhang J, Wang Y, Peng Q, Korean J. Chem. Eng., 30(6), 1284, 2013
  15. Albertsson PA, Partition of cell particles and macromolecules: separation and purification of biomolecules, cell organelles, membranes, and cells in aqueous polymer two-phase systems and their use in biochemical analysis and biotechnology, 346. Wiley New York etc. (1986).
  16. Karkas T, Onal S, Biochem. Eng. J., 60, 142, 2012
  17. Beijerinck MW, Uber eine Eigentumlichkeit der loslichen Starke, Centr-Bl. F. Bakter. U. Parasitenk, 2 (1896).
  18. Zaslavsky BY, Aqueous two-phase partitioning: physical chemistry and bioanalytical applications, CRC Press (1994).
  19. Asenjo JA, Andrews BA, J. Chromatogr. A, 1218, 8826, 2011
  20. Silverio SC, Ferreira LA, Martins JA, Marcos JC, Macedo EA, Teixeira JA, Fluid Phase Equilib., 322, 19, 2012
  21. de Barros DP, Campos SR, Madeira PP, Azevedo AM, Baptista AM, Aires-Barros MR, J. Chromatogr. A, 1329, 52, 2014
  22. Nitsawang S, Hatti-Kaul R, Kanasawuda P, Enzyme Microb. Technol., 39(5), 1103, 2006
  23. Zafarani-Moattar MT, Shekaari H, Hashemzadeh T, Fluid Phase Equilib., 459, 85, 2018
  24. Waziri SM, Abu-Sharkh BF, Ali SA, Fluid Phase Equilib., 205(2), 275, 2003
  25. Rahmani A, Rostami AA, Pirdashti M, Mobalegholeslam P, Korean J. Chem. Eng., 34(4), 1149, 2017
  26. Se RA, Aznar M, Korean J. Chem. Eng., 47, 1401, 2002
  27. Shanbhag VP, Axelsson CG, Eur. J. Biochem., 60, 17, 1975
  28. Sadeghi R, Fluid Phase Equilib., 246(1-2), 89, 2006
  29. Sosa FHB, Sampaio DD, Farias FO, Bonassoli ABG, Igarashi-Mafra L, Mafra MR, Fluid Phase Equilib., 449, 68, 2017
  30. Li M, Zhu ZQ, Wu YT, Lin DQ, Chem. Eng. Sci., 53(15), 2755, 1998
  31. Khayati G, Chem. Eng. Commun., 200(5), 667, 2013
  32. Haghtalab A, Mokhtarani B, Maurer G, J. Chem. Eng. Data, 48(5), 1170, 2003
  33. Duran A, Claros M, Jimenez YP, J. Mol. Liq., 249, 562, 2018
  34. Lee SC, Ahn BS, Kim JG, Biotechnol. Prog., 18(1), 108, 2002
  35. Yang CF, Cussler EL, Biotechnol. Bioeng., 69(1), 66, 2000
  36. Silvestri HH, US Patent, 3,862,186 (1975).
  37. Ghosh AC, Mathur RK, Dutta NN, Extraction and purification of cephalosporin antibiotics, Springer, Regional Research Laboratory, India, 111 (1997).
  38. Klomklao S, Benjakul S, Visessanguan W, Simpson BK, Kishimura H, Process Biochem., 40(9), 3061, 2005
  39. Han J, Wang Y, Kang W, Li C, Yan Y, Pan J, Xie XJ, Microchim. Acta, 169, 15, 2010
  40. Arnold T, Linke DJB, Biotechniques, 43, 427, 2007
  41. Li S, He C, Liu H, Li K, Liu F, J. Chromatogr. B, 826, 58, 2005
  42. Doozandeh SG, Pazuki G, Madadi B, Rohani AA, J. Mol. Liq., 174, 95, 2012
  43. Khederlou K, Pazuki GR, Taghikhani V, Vossoughi M, Ghotbi C, J. Chem. Eng. Data, 54(8), 2239, 2009
  44. Shoushtari BA, Shahrouzi JR, Pazuki G, J. Chem. Eng. Data, 61(7), 2605, 2016
  45. Murari GF, Penido JA, Machado PAL, de Lemos LR, Lemes NHT, Virtuoso LS, Rodrigues GD, Mageste AB, Fluid Phase Equilib., 406, 61, 2015
  46. Zafarani-Moattar MT, Hamzehzadeh S, Hosseinzadeh S, Fluid Phase Equilib., 268(1-2), 142, 2008
  47. Messnaoui B, Ouiazzane S, Bouhaouss A, Bounahmidi T, Calphad., 32, 566, 2008
  48. Guo B, Chen L, Liu Y, Yan Z, J. Solution Chem., 46, 1059, 2017
  49. Hamta A, Mohammadi A, Dehghani MR, Feyzi F, J. Solution Chem., 47, 1, 2017
  50. Prausnitz JM, Lichtenthaler RN, de Azevedo EG, Molecular thermodynamics of fluid-phase equilibria, Pearson Education (1998).
  51. Zafarani-Moattar MT, Sadeghi R, Hamidi AA, Fluid Phase Equilib., 219(2), 149, 2004
  52. Wu YT, Lin DQ, Zhu ZQ, Fluid Phase Equilib., 147(1-2), 25, 1998
  53. Haghtalab A, Joda M, Fluid Phase Equilib., 278(1-2), 20, 2009
  54. Seyf JY, Haghtalab A, J. Chem. Eng. Data, 61(6), 2170, 2016
  55. Renon H, Prausnitz JM, AIChE J., 14, 135, 1968
  56. Flory PJ, J. Chem. Phys., 10, 51, 1942
  57. Singh R, Darbari G, Verma G, J. Chem. Phys., 46, 151, 1967
  58. Pazuki GR, Taghikhani V, Vossoughi M, Alemzadeh I, Chem. Eng. Res. Des., 87(3A), 335, 2009
  59. Taghavivand M, Pazuki G, Fluid Phase Equilib., 379, 62, 2014
참고문헌정보(참고문헌, 인용문헌)는 화학공학소재연구정보센터에 의해 제공되고 있습니다.