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Issue
Korean Journal of Chemical Engineering,
Vol.34, No.7, 1889-1895, 2017
Preparation of cationic functional polymer poly(Acryloxyethyltrimethyl ammonium chloride)/SiO2 and its adsorption characteristics for heparin
Men J, Guo J, Zhou W, Dong N, PAng X, Gao B
Ion-exchange is a widely used purification technology in the heparin manufacturing process. To improve the rate and efficiency, the cationic monomer Acryloxyethyltrimethyl ammonium chloride (DAC) was grafted on silica gel particles by using a surface-initiated graft-polymerization technique, and a novel adsorption polymer of PDAC/SiO2 was prepared. The adsorption experiments of PDAC/SiO2 for heparin show that there are strong electrostatic interactions between heparin with a high density of negative charges and PDAC/SiO2 that exists in many quaternary ammonium cations. Comparing the adsorption kinetics of PDAC/SiO2 with D201 anionic strong alkali exchange resin, PDAC/SiO2 shows higher adsorption capacity and faster adsorption rate. The pH and temperature of solutions have a great influence on the adsorption amount, and there is a maximum adsorption capacity of 121mg/g when pH=7 at 25 °C. The adsorption of PDAC/SiO2 for heparin is an exothermic process and driven by entropy.
Keywords: Heparin; Cationic Monomer; Electrostatic Interaction; DAC; Adsorption
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