The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.
Albu MG, Ferdes M, Kaya DA, Ghica MV, Titorencu I, Popa L, Albu L, Mol. Cryst. Liq. Cryst., 555(1), 271, 2012
Ardalan A, Omid A, Golnaz A, Mahdi Z, J. Essent. Oil Bear Pl., 16(1), 59, 2013
Clardy J, Walsh C, Nature, 432(7019), 829, 2004
Gennadios A, McHugh TH, Weller CL, Krochta JM, Edible coatings and films based on proteins, Krochta JM, Baldwin EA, Nisperos-Carriedo M (Eds.), Edible coatings and films to improve food quality, Technomic Publishing Co., Lancaster (1994).
Ghica MV, Albu MG, Leca M, Popa L, Moisescu S, Pharmazie, 66(11), 853, 2011
Ghica MV, Albu MG, Coara G, Dinu-Pirvu C, Proceedings of the 4th International Conference on Advanced Materials and Systems (ICAMS), Bucharest, September 27-29, 267 (2012).
Ahadian S, Mohseni M, Moradian S, Int. J. Adhes. Adhes., 29(4), 458, 2009