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Korean Journal of Chemical Engineering, Vol.39, No.11, 3067-3073, 2022
Ultrasonic cavitation bubble- and gas bubble-assisted fractional precipitation for the purification of (+)-dihydromyricetin
This study presents the ultrasonic cavitation bubble- and gas bubble-assisted fractional precipitation that dramatically improves the precipitation efficiency in existing precipitation method for purifying (+)-dihydromyricetin. Compared to the conventional method, the time required for precipitation was reduced by 40 times. The particle size was reduced by 4.0-7.4 times and 3.7-4.4 times for cavitation bubbles and gas bubbles, respectively, and the diffusion coefficient was increased by 5.1-9.2 times (cavitation bubble) and 3.7-4.4 times (gas bubble). Meanwhile, the precipitation rate constant was increased by 11.0-65.0 times and 17.0-24.6 times and the activation energy was decreased by -5,543~-9,655 J/mol and -6,546~-7,404 J/mol, which resulted in an improved precipitation rate. The results of the thermodynamic analysis showed that the precipitation was exothermic and non-spontaneous.
[References]
- Zheng XJ, Xiao H, Zeng Z, Sun ZW, Lei C, Dong JZ, Wang Y, J. Funct. Foods, 9, 290, 2014
- Li F, Raza A, Wang YW, Xu XQ, Chen GH, Phcog. Mag., 13, 446, 2017
- Ji SB, Kim JH, Korean J. Chem. Eng. Res., 56, 370, 2018
- Du Q, Cai W, Xia M, Ito Y, J. Chromatogr. A, 973, 217, 2002
- Yohsikawa M, Murakami T, Chem. Pharm. Bull., 44, 1736, 1996
- Lee KH, Kim JH, Biotechnol. Bioprocess Eng., 13, 274, 2008
- Lim MK, Kim JH, Korean J. Microbiol. Bioteachnol., 42, 25, 2014
- Seo HW, Kim JH, Process Biochem., 87, 238, 2019
- Schueller BS, Yang RT, Ind. Eng. Chem. Res., 40, 4912, 2001
- Dalvi SV, Dave RN, Int. J. Pharm., 387, 172, 2010
- Oh SR, Kim JH, Korean J. Chem. Eng., 38, 480, 2021
- Jordens J, Coker ND, Gielen B, Gerven TV, Braeken L, Ultrason. Sonochem., 26, 64, 2001
- Kang HJ, Kim JH, Process Biochem., 99, 316, 2020
- Lee CG, Kim JH, Process Biochem., 59, 216, 2017
- Park JN, Kim JH, Process Biochem., 53, 224, 2017
- Wohlgemuth K, Ruether F, Schembecker G, Chem. Eng. Sci., 65, 1016, 2010
- Min HS, Kim JH, Korean J. Chem. Eng., 39, 58, 2022
- Wohlgemuth K, Kordylla A, Ruether F, Schembecker G, Chem. Eng. Sci., 64, 4155, 2009
- Guo Z, Zhang M, Li H, Wang J, Kougoulos E, J. Cryst. Growth, 273, 555, 2005
- Khadka P, Ro J, Kim H, Kim I, Kim JT, Kim H, Cho JM, Yun G, Lee J, Asian J. Pharm. Sci., 9, 3004, 2014
- Kim MJ, Kim JH, Korean Chem. Eng. Res., 54, 278, 2016
- Ma D, Marshall JS, Wu J, J. Acoust. Soc. Am., 114, 3496, 2018
- Guo Z, Jones AG, Li N, Chem. Eng. Sci., 61, 1617, 2008
- Wolloch L, Kost J, J. Control. Release, 148, 204, 2010
- Yoon TH, Kim JH, Biotechnol. Bioprocess Eng., 25, 777, 2020
- Petrou AL, Terzidaki A, Chem. Geol., 381, 144, 2014
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