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Korean Journal of Chemical Engineering, Vol.35, No.1, 204-209, 2018
Effective separation of succinic acid by combined crystallization
Succinic acid, which is widely used as a building block chemical, can be produced from either petroleum or renewable resources. Bio-based production of succinic acid requires several purification steps, and the yield of any particular separation method is an important factor in facilitating an economic design. Crystallization is a common method for the purification of succinic acid, and several driving forces can be used to generate solubility changes in the solution. In this work, three driving forces of crystallization - cooling, acidification, and salting out - were examined individually and combined to achieve maximum yield from a solution of succinic acid. It was found that combined crystallization can significantly improve the yield (97.08%) compared with conventional cooling crystallization (84.31%) or acidification (66-67%). Additionally, a basic kinetic study was performed, and a total of 7minutes of batch operation was sufficient to produce the maximum amount of crystals.
[References]
- Sauer M, Porro D, Mattanovich D, Branduardi P, Trends Biotechnol., 26, 100, 2008
- Cheng KK, Zhao XB, Zeng J, Zhang JA, Bioprod. Bioref., 6, 302, 2012
- Willke T, Vorlop KD, Appl. Microbiol. Biotechnol., 66(2), 131, 2004
- Sun YQ, Yan L, Fu HX, Xiu ZL, Process Biochem., 49(3), 506, 2014
- Bechthold I, Bretz K, Kabasci S, Kopitzky R, Springer A, Chem. Eng. Technol., 31(5), 647, 2008
- Kertes A, King CJ, Biotechnol. Bioeng., 28, 269, 1986
- Huh YS, Jun YS, Hong YK, Song H, Lee SY, Hong WH, Process Biochem., 41(6), 1461, 2006
- Jun YS, Lee EZ, Huh YS, Hong YK, Hong WH, Lee SY, Biochem. Eng. J., 36, 8, 2007
- Song H, Huh YS, Lee SY, Hong WH, Hong YK, J. Biotechnol., 132, 445, 2007
- Hong YK, Hong WH, Sep. Purif. Technol., 42(2), 151, 2005
- Hong YK, Han DH, Hong WH, Korean J. Chem. Eng., 19(1), 83, 2002
- Hong YK, Hong WH, Korean J. Chem. Eng., 21, 488, 2002
- Pratiwi AI, Yokouchi T, Matsumoto M, Kondo K, Sep. Purif. Technol., 155, 127, 2015
- Luque R, Lin CSK, Du C, Macquarrie DJ, Koutinas A, Wang R, Webb C, Clark JH, Green Chem., 11, 193, 2009
- Li Q, Wang D, Wu Y, Li WL, Zhang YJ, Xing JM, Su ZG, Sep. Purif. Technol., 72(3), 294, 2010
- Schlosser S, Kertesz R, Martak J, Sep. Purif. Technol., 41(3), 237, 2005
- Berglund KA, Elankovan P, Glassner DA, U.S. Patent No. 5034105 A (1991).
- Efe C, Pieterse M, van der Wielen LAM, Straathof AJJ, Chem. Eng. Process., 50(11-12), 1143, 2011
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