Biomedical electronic devices integrated with specific human body parts have attracted considerable attention because they present significant breakthroughs to solve various clinical challenges. Recent innovations in soft nanomaterial assemblies, novel device design strategies, and clinically relevant system-level applications have accelerated the rapid growth in this research field. In particular, novel biomedical functionalities, such as extraordinary sensitivity in diagnosis and outstanding therapy performance, could be achieved through wearable, implantable, and minimally invasive bioelectronics. Monolithic integration of functional nanomaterial assemblies with flexible and stretchable device platforms has enabled these breakthroughs. This review first presents a brief history and then provides more details of recent advancements in nanomaterial assemblies and their applications to soft bioelectronics. Important technological advances to solve unmet clinical challenges are presented by leveraging soft bioelectronics toward the next-generation medical systems.
Webb RC, Ma Y, Krishnan S, Li Y, Yoon S, Guo X, Feng X, Shi Y, Seidel M, Cho NH, Kurniawan J, Ahad J, Sheth N, Kim J, Taylor JG VI, Darlington T, Chang K, Huang W, Ayers J, Gruebele A, Pielak RM, Slepian MJ, Huang Y, Gorbach AM, Rogers JA, Sci. Adv., 1, e15007, 2015
Viventi J, Kim DH, Vigeland L, Frechette ES, Blanco JA, Kim YS, Avrin AE, Tiruvadi VR, Hwang SW, Vanleer AC, Wulsin DF, Davis K, Gelber CE, Palmer L, Van der Spiegel J, Wu J, Xiao J, Huang Y, Contreras D, Rogers JA, Litt B, Nat. Neurosci., 14, 1599, 2011
Lee H, Choi TK, Lee YB, Cho HR, Ghaffari R, Wang L, Choi HJ, Chung TD, Lu N, Hyeon T, Choi SH, Kim DH, Nat. Nanotech., 11, 566, 2016
Kim J, Lee M, Shim HJ, Ghaffari R, Cho HR, Son D, Jung YH, Soh M, Choi C, Jung S, Chu K, Jeon D, Lee ST, Kim JH, Choi SH, Hyeon T, Kim DH, Nat. Commun., 5, 5747, 2014
Song JK, Son D, Kim J, Yoo YJ, Lee GJ, Wang L, Choi MK, Yang J, Lee M, Do K, Koo JH, Lu N, Kim JH, Hyeon T, Song YM, Kim DH, Adv. Funct. Mater., 27, 160528, 2017
Jung S, Hong S, Kim J, Lee S, Hyeon T, Lee M, Kim DH, Sci. Rep., 5, 17081, 2015
Choi MK, Park OK, Choi C, Qiao S, Ghaffari R, Kim J, Lee DJ, Kim M, Hyun W, Kim SJ, Hwang HJ, Kwon SH, Hyeon T, Lu N, Kim DH, Adv. Healthc. Mater., 5, 80, 2016
Kim SJ, Cho HR, Cho KW, Qiao S, Rhim JS, Soh M, Kim T, Choi MK, Choi C, Park I, Hwang NS, Hyeon T, Choi SH, Lu N, Kim DH, ACS Nano, 9, 2677, 2015
Jang KI, Chung HU, Xu S, Lee CH, Luan H, Jeong J, Cheng H, Kim GT, Han SY, Lee JW, Kim J, Cho M, Miao F, Yang Y, Jung HN, Flavin M, Liu H, Kong GW, Yu KJ, Rhee SI, Chung J, Kim B, Kwak JW, Yun MH, Kim JY, Song YM, Paik U, Zhang Y, Huang Y, Rogers JA, Nat. Commun., 6, 6566, 2015
Norton JJS, Lee DS, Lee JW, Lee W, Kwon O, Won P, Jung SY, Cheng H, Jeong JW, Akce A, Umunna S, Na I, Kwon YH, Wang XQ, Liu Z, Paik U, Huang Y, Bretl T, Yeo WH, Rogers JA, Proc. Natl. Acad. Sci. U.S.A., 112, 3920, 2015
Son D, Lee J, Qiao S, Ghaffari R, Kim J, Lee JE, Song C, Kim SJ, Lee DJ, Jun SW, Yang S, Park M, Shin M, Do K, Lee M, Kang K, Hwang CS, Lu N, Hyeon T, Kim DH, Nat. Nanotech., 9, 397, 2014
Kim J, Shim HJ, Yang J, Choi MK, Kim DC, Kim J, Hyeon T, Kim DH, Adv. Mater. (2017), DOI:10.1002/adma.201700217.
Kim TH, Lee CS, Kim S, Hur J, Lee S, Shin KW, Yoon YZ, Choi MK, Yang J, Kim DH, Hyeon T, Park S, Hwang S, ACS Nano, 11, 5992, 2017
Lee SS, Reuveny A, Reeder J, Lee SS, Jin H, Liu Q, Yokota T, Sekitani T, Isoyama T, Abe Y, Suo Z, Someya T, Nat. Nanotech., 11, 472, 2016
Persano I, Dagdeviren C, Su Y, Zhang Y, Girardo S, Pisignano D, Huang Y, Rogers JA, Nat. Commun., 4, 1633, 2013
Kim DH, Lu N, Huang Y, Rogers JA, MRS Bull., 37, 226, 2012
Lopez-Sanchez O, Lembke D, Kayci M, Radenovic A, Kis A, Nat. Nanotech., 8, 497, 2013
Yu KJ, Kuzum D, Hwang SW, Kim BH, Juul H, Kim NH, Won SM, Chiang K, Trumpis M, Richardson AG, Cheng H, Fang H, Thompson M, Bink H, Talos D, Seo KJ, Lee HN, Kang SK, Kim JH, Lee JY, Huang Y, Jensen FE, Dichter MA, Lucas TH, Viventi J, Litt B, Rogers JA, Nat. Mater., 15, 872, 2016
Park J, Choi S, Janardhan AH, Lee SY, Raut S, Soares J, Shin K, Yang S, Lee C, Kang KW, Cho HR, Kim SJ, Seo P, Hyun W, Jung S, Lee HJ, Lee N, Choi SH, Sacks M, Lu N, Josephson ME, Hyeon T, Kim DH, Hwang HJ, Sci. Transl. Med., 8, 344ra8, 2016
Lee H, Lee Y, Song C, Cho HR, Ghaffari R, Choi TK, Kim KH, Lee YB, Ling D, Lee H, Yu SJ, Choi SH, Hyeon T, Kim DH, Nat. Commun., 6, 10059, 2015
Kim DH, Lu NS, Ma R, Kim YS, Kim RH, Wang SD, Wu J, Won SM, Tao H, Islam A, Yu KJ, Kim TI, Chowdhury R, Ying M, Xu LZ, Li M, Chung HJ, Keum H, McCormick M, Liu P, Zhang YW, Omenetto FG, Huang YG, Coleman T, Rogers JA, Science, 333(6044), 838, 2011
Canales A, Jia X, Froriep UP, Koppes RA, Tringides CM, Selvidge J, Lu C, Hou C, Wei L, Fink Y, Anikeeva P, Nat. Biotechnol., 33, 277, 2015
Lu C, Park S, Richner TJ, Derry A, Brown I, Hou C, Rao S, Kang J, Mortiz CT, Fink Y, Anikeeva P, Sci. Adv., 3, e16009, 2017
Park M, Do K, Kim J, Son D, Koo JH, Park J, Song JK, Kim JH, Lee M, Hyeon T, Kim DH, Adv. Healthc. Mater., 4, 992, 2015
Xu L, Gutbrod SR, Bonifas AP, Su Y, Sulkin MS, Lu N, Chung HJ, Jang KI, Liu Z, Ying M, Lu C, Webb RC, Kim JS, Laughner JI, Cheng H, Liu Y, Ameen A, Jeong JW, Kim GT, Huang Y, Efimov IR, Rogers JA, Nat. Commun., 5, 3329, 2014
Son D, Lee J, Lee DJ, Ghaffari R, Yun S, Kim SJ, Lee JE, Cho HR, Yoon S, Yang S, Lee S, Qiao S, Ling D, Shin S, Song JK, Kim J, Kim T, Lee H, Kim J, Soh M, Lee N, Hwang CS, Nam S, Lu N, Hyeon T, Choi SH, Kim DH, ACS Nano, 9, 5937, 2015
Park SI, Brenner DS, Shin G, Morgan CD, Copits BA, Chung HU, Pullen MY, Noh KN, Davidson S, Oh SJ, Yoon J, Jang KI, Samineni VK, Norman M, Grajales-Reyes JG, Vogt SK, Sundaram SS, Wilson KM, Ha JS, Xu R, Pan T, Kim TI, Huang Y, Montana MC, Golden JP, Bruc, Nat. Biotechnol., 33, 1280, 2015
Liu J, Fu TM, Cheng Z, Hong G, Zhou T, Jin L, Duvvuri M, Jiang Z, Kruskal P, Xie C, Suo Z, Fang Y, Lieber CM, Nat. Nanotech., 10, 629, 2015
Kim KS, Zhao Y, Jang H, Lee SY, Kim JM, Kim KS, Ahn JH, Kim P, Choi JY, Hong BH, Nature, 457, 706, 2009
Gong S, Schwalb W, Wang Y, Chen Y, Tang Y, Si J, Shirinzadeh B, Cheng W, Nat. Commun., 5, 3132, 2014
Bae S, Kim H, Lee Y, Xu X, Park JS, Zheng Y, Balakrishnan J, Lei T, Kim HR, Song YI, Kim YJ, Kim KS, Ozyilmaz B, Ahn JH, Hong BH, Iijima S, Nat. Nanotech., 5, 574, 2010