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Korean Journal of Chemical Engineering, Vol.23, No.3, 482-487, 2006
Crystallization of acetaminophen micro-particle using supercritical carbon dioxide
Fine particles of acetaminophen were produced by Aerosol Solvent Extraction System (ASES). The experiments were conducted to investigate the effects of various temperatures, pressures, solvents, solution concentrations and solution feed volume rates on particle size and morphology. The choice of solvent appears to be very important for getting specific particle shape and size. The result shows that when ethyl acetate is used as a solvent, the irregular and acicular morphology of raw material is recrystallized to be regular and monoclinic. The average particle size of recrystallized acetaminophen from ethyl acetate solution has been measured to be 3-4 μm, which was about 1/20th of raw acetaminophen in size. The particle size distribution range also became narrow from 82 μm to 4.9 μm.
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[Cited By]
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- Kang DY, Min BJ, Rho SG, Kang CH, Korean Chemical Engineering Research, 46(5), 958, 2008
- Shin MS, KiM HY, Clean Technology, 14(4), 242, 2008
- Chu J, Lee H, Kim H, Lee YW, Korean Journal of Chemical Engineering, 26(4), 1119, 2009
- Kim CK, Lee BC, Lee YW, Kim HS, Korean Journal of Chemical Engineering, 26(4), 1125, 2009
- Kwon KT, Uddin MS, Jung GW, Chun BS, Korean Journal of Chemical Engineering, 28(10), 2044, 2011
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