Simulated moving bed(SMB) chromatography was simulated for separating loxoprofen racemates. Aspen chromatography simulator was utilized with Henry’s constants of loxoprofen racemates which were obtained by batch chromatography experiments. Raffinate stream concentrations as well as purities were calculated with various m2 and m3 values in the triangle diagram obtained from two Henry’s constants 7.9 and 10.1. Purity values are high under the conditions that the m2-m3 coordinates are near the left central region in the diagram and feed flow rates are lower. Concentration profiles of raffinate and extract streams along SMB columns explain the purity change in the case of increasing the column numbers installed at SMB.