The fully thermally coupled distillation columns(FTCDC) are thermodynamically more efficient than conventional columns. Despite these advantages, industry has been reluctant to use FTCDC. This can be largely attributed to the lack of established design procedures and column operability. In this study, the 3×3 control structure was applied to control the FTCDC which was simulated using Aspen HYSYS on the possible control structure of 4 kinds and control performance was investigated. As the result of dynamic simulations, one of the proposed structures had better controllability of product compositions and control efficiency was evaluated.