Hollow fiber membrane G-L contactors are widely used to remove SO2 emitted from industrial facilities. In this work, the mathematical modeling and computer simulation for hollow membrane G-L contactors is carried out to analyze SO2 absorption behavior in hollow fiber membranes. The model is solved with the finite element method using a commercial software. Investigated is the dependency of SO2 removal efficiency and mass transfer characteristics on gas velocities, membrane mass transfer coefficients and physical properties of contactors. The membrane mass transfer coefficients are estimated by fitting the experimental data with the simulated SO2 removal efficiencies. In addition, a design methodology of membrane contactors is suggested.