About The Journal
  Aims and Scope
  Editorial Board
  Submit a Manuscript 
  Subscription Information
Articles & Issues
  Issue
  Search
For Authors
  Instructions to Authors
  Ethics in Publishing
  Peer Review Process
  Author's Checklist
  Copyright Transfer Form
Contact us
 
 
 
 
Search / Korean Journal of Chemical Engineering
Korean Chemical Engineering Research,
Vol.42, No.2, 151-162, 2004
진동에 의한 혈관 내 폐 보조장치의 산소전달 특성
Characteristics of Oxygen Transfer in Intravascular Lung Assist Device by Vibrating
김기범, 권대규, 이삼철, 김성종, 정인수, 오인혁, 김기주, 변윤섭, 정경락
본 연구는 급성호흡부전환자를 치료하기 위하여 사용되고 있는 혈관 내 폐 보조장치의 기체전달을 향상시키기 위하여 중공사 막에 진동기법을 사용하여 기체전달을 향상시키고자 시도하였다. 그리고 혈관 내 폐 보조장치를 정맥에 삽입하기 전, 혈관 내 폐 보조장치의 설계조건을 실험적 모델을 통하여 기체전달을 예측할 수 있는 예측식을 만들고자 하였다. 실험결과, 본 연구에서는 진동기법이 기체전달을 향상시키는데 효과적임을 확인할 수 있었다. 뿐만 아니라, 충진율과 가진 주파수의 함수관계를 이용하여 기체전달을 예측할 수 있었다. 실험에 의하여 얻어진 결과는 예측 식에 의하여 얻어진 결과와 유사한 결과를 얻었다. 그러므로 본 연구에서는 충진율과 가진 주파수의 함수를 이용하여 VIVALD의 기체전달을 예측할 수 있었다.
In this paper, we tried to improve gas exchange of the vibrating intravascular lung assist device(VIVLAD) using vibrating method in the hollow fiber membrane, for the patients suffering from acute respiratory distress syndrome(ARDS). And we tried to formularize prediction equations to make a prediction about gas transfer for designing intravenous artificial lung assist device, and designed modules under various conditions were studied through an experimental modeling before inserted the artificial lung assist device into as venous. As a result, we are convinced that vibration method is very useful for the gas transfer increasing. Also, we can estimate the gas transfer as a function of the packing density and excited frequencies. The gas transfer obtained from the experiment was similar to that from the prediction equation, confirming the usefulness prediction equation. Therefore, we can estimate the gas transfer of the VIVLAD as a function of the packing density and excited frequencies.
Keywords: Artificial Lung; Gas Transfer; Vibrating Method; ARDS
[References]
  1. Bartlett RH, Roloff DW, Cornell RG, Andrews AF, Dillon PW, Zwischenberger AB, Pediatrics, 4, 479, 1985
  2. Pearson GD, Short BL, J. Intens. Care. Med., 2, 116, 1986
  3. Finder NN, Tierney AJ, Hallgren R, Hayashi A, Peliowski A, Etches PC, Can. Med. Assoc. J., 146, 1992
  4. Campell TG, ASAIO J., 40, 109, 1994
  5. Fedespiel WJ, Hout MS, Hewitt TJ, Lund LW, Leinrich SA, Litwak P, Walters FR, Reeder GD, Borovetz HS, Hattler BG, ASAIO J., 43, M725, 1997
  6. Hewitt TJ, Hattler BG, Federspiel WJ, Annu. Biomed. Eng., 26, 166, 1998
  7. Vaslef SN, Mockros LF, Anderson RW, Trans. Am. Soc. Artif. Intern. Organs, 35, 660, 1989
  8. Federspiel WJ, Hewitt TJ, Hout MS, Walters FR, ASAIO J., 42, M435, 1996
  9. Federspiel WJ, Williams JL, Hattler BG, AIChE J., 42(7), 2094, 1996
  10. Nodelman V, Baskaran H, Ultman JS, Annals Biomed. Eng., 26, 1044, 1998
  11. Vaslef SN, Cook KE, Leonard RJ, Mockros LF, Anderson RW, ASAIO J., 40, M522, 1994
  12. Federspiel WJ, Lund LW, Bultman JA, Wanant S, Matoney J, Golob JF, Frankowski BJ, Watach M, Litwak P, Hattler BG, ASAIO J., 45, 127, 1999
  13. Lee SC, Kim KB, Hong SC, Kim MH, Jheong GR, J. Biomed. Eng. Res., 21(3), 311, 2000
  14. Mortensen JD, Trans. Am. Soc. Artif. Intern. Organs., 33, 570, 1987
  15. Mortensen JD, Artif. Organs, 16, 75, 1992
  16. Vaslef SN, Mockros LF, Anderson RW, Trans. Am. Soc. Artif. Intern. Organs, 35, 660, 1989
  17. Snider MT, M.T. U.S. Patent, Application, Serial No. WO 93/13,828, 1993
  18. http://www.eurekalert.org/pub_releases/2002-06/uomh-ual061002.php
  19. Nodelman V, Baskaran H, Ultman JS, Annals Biomed. Eng., 26, 1044, 1998
  20. Vaslef SN, Mockros LF, Cook KE, Leonard RJ, Sung JC, Anderson RW, Artif. Organs, 18(11), 813, 1994
  21. Katoh S, Yoshida F, Chem. Eng. J., 3, 51, 1972
  22. McCabe WL, Smith JC, Harriott P, Unit Operation of Chemical Engineering, 5th ed., McGraw-Hill Inc., New York, 1993
  23. Streeter VL, Wylie EB, Bedford K, Fluid Mechanics, 9th ed., McGraw-Hill, Inc., New York, 1998
  24. Bird RB, Stewart WE, Lightfoot EN, Transport Phenomena, 2th ed., John Wiley & Sons, Inc., New York, 2002
  25. Mulder M, Basic Principles of Membrane Technology, Kluwer Academic, Netherlands, 1996
  26. Beek WL, Muttzell KMK, vanHeuven JW, Transport Phenomena, 2th ed., John Wiley & Sons (ASIA) PTE LTD, Singapore, 1999
  27. Wickramasinghe SR, Kahr CM, Han BB, Biotechnol. Prog., 18(4), 867, 2002
  28. Kim GB, Kwon TK, Jheong GR, Lee SC, J. Biomed. Eng. Res., 24(2), 121, 2003
  29. Park JK, Kim GB, Kwon TK, Hong SC, Jheong GR, Lee SC, Theor. Appl. Chem. Eng., 2(2), 5070, 2002
  30. Kim GB, Kwon TK, Park JK, Jheong GR, Lee SC, Membrane, 13(1), 20, 2003
  31. Kim GB, Kwon TK, Jheong GR, J. Biomed. Eng. Res., 24(4), 293, 2003
  32. AAMI Standard: Cardionascular/Neurology Standards for Blood/Gas Exchanger Devices (Oxygenators); August 14, 1998
  33. ISO/DIS 7199 International Standard: Cardiovascular Implantants and Artificial Organs-Blood-Gas Exchangers, 1996
  34. Nollet LML, Handbook of water analysis: Chemical Parameter's by de Medina, H.L., N.Y., Darcel Deker, 2000
  35. Vaslef SN, Analysis and Designs of an Intravascular Lung Asisst Device, Ph.D. Dissertation, 1990
  36. Vennard JK, Street RL, Elementary Fluid Mechanics, 6th ed., John Wiley & Sons Inc., New York, 1995
  37. Ciuryla VT, Oxygen Diffusion in Human Blood Plasma, Ph.D. Dissertation, Northwestern University, 1971
[Cited By]
  1. Kim GB, Park JK, Kim SJ, Kim JS, You IS, Kim MH, Hong CU, Kim JS, Kang HS, Korean Chemical Engineering Research, 46(3), 626, 2008
  2. Kim GB, Park YR, Kim SJ, Hong CU, Kang HS, Kim JS, Kim SJ, Kim MH, Korean Chemical Engineering Research, 49(2), 230, 2011
  3. Park YR, Shim J, Kim GB, Kim SJ, Kang HS, Kim JS, Kim MH, Hong CU, Kim SJ, Korean Chemical Engineering Research, 49(2), 238, 2011
참고문헌정보(참고문헌, 인용문헌)는 화학공학소재연구정보센터에 의해 제공되고 있습니다.