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Search / Korean Journal of Chemical Engineering
Korean Chemical Engineering Research,
Vol.42, No.2, 129-138, 2004
간세포 배양기술을 이용한 생인공간 개발 현황
Hepatocyte Culture Technology and its Application to Bioartificial Liver
이두훈, 윤희훈, 박정극
우리 인체의 장기 중 간(liver)은 생존에 그 어느 장기보다도 중요한 역할을 담당하는 장기로서 여러 가지 원인으로 인하여 갑자기 간의 기능이 상실된 환자에게는 간이식만이 유일한 대안이다. 간세포를 이용한 체외 순환형 간 보조 장치(생인공간, bioartificial liver)는 최근 유일하게 전격성 간부전 환자의 생존율 증대 효과가 검증되었고 간이식이나 환자 자신의 간 재생으로의 생명 연장 교량 역할을 효과적으로 수행할 수 있을 것으로 기대되고 있다. 본 논문에서는 생인공간의 개념과 임상시험 중인 대표적인 생인공간 시스템 현황에 대해서 공학적 관점 위주로 소개하고 향후 이 분야에 대한 연구전망에 대하여 서술하였다.
The liver is mutifunctional vital organ for healthy survival and orthotopic liver transplatation is the only definitive therapy for patients with acute or fulminant failure (FHF) so far. Bioartificial liver, a hepatocyte-based extracorporeal liver support system, enhanced the survival rates of patients with FHF and expected to act as a bridge to provide the extension of survival time until a donor organ becomes available for transplantation or their own liver can be regenerated. In this paper, we introduce concepts of bioartificial liver and review representative bioartificial liver systems in clinical trial s with engineering issue. Finally we describe future perspectives of bioartificial liver.
Keywords: Bioartificial Liver; Fulminant Hepatic Failure; Hepatocyte Spheroid; Hepatic Stem Cell; Hepatocyte Bioreactor
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