Solvent extraction of heptavalent Rhenium(Re) from the simulated solution by the tributyl phosphate in n-dode-cane(TBP/NDD) was studied to find the effects of co-existing elements and an effective condition for the only co-extraction of U and Re. The extraction yields of Re(E_Re) increase with concentration of nitric acid until a maximum is reached at 1 M HNO₃. Above 1 M HNO₃, E_Re decrease rapidly because of depletion of free TBP available to extract Re due to the competition reaction of TBP and nitric acid. E_Re is about 16.5 % at 30 % TBP and 2 M HNO₃ and increase with free TBP concentration, and with the ratio of organic phase volume to aqueous phase volume(O/A). It has no effect with concentration of Re. In the presence of U or Zr, it is found that Re is extracted as a complex with then in the organic phase, and Re is more strongly bound to Zr than U. In the presence of both U and Zr, however, E_Re increase with concentration of Zr and has no effect with concentration of U. It is also found that the extraction of Re is affected by only Zr. At O/A=1.5, the extraction yields of U and Re are about 44.1 % and 98.1 %, respectively, and those of Fe, Mo, Nd, Y, Cs and Sr are below 5 %. Therefore, optimal condition for the only co-extraction of U and Re is O/A=1.5.