Search / Korean Journal of Chemical Engineering
HWAHAK KONGHAK,
Vol.41, No.6, 679-688, 2003
초임계유체를 이용한 입자제조
Design of Particles using Supercritical Fluids
초임계이산화탄소와 초임계수와 같은 초임계유체의 환경친화적 성질은 미세입자를 제조하는 새로운 재료분야의 응용에 많은 관심의 대상이 되고 있다. 최근에는 초임계유체의 저독성과 불연성 그리고 저렴한 가격 때문에 의약품, 화장품, 세라믹, 식품 그리고 폭약 등에서 이를 이용하여 나노 또는 마이크로입자를 제조하는 공정에 많은 이용되고 있다. 본고에서는 초임계유체를 이용하여 미세입자를 제조하는 대표적인 공정인 RESS(rapid expansion of supercritical solutions), SAS(supercriticalanti solvent) 그리고 PGSS(particles from gas saturated solutions)등에 대하여 중점적으로 소개하고자 한다.
The environmentally friendly nature of supercritical fluids such as supercritical carbon dioxide and supercritical water has led to the exploration of their use in a range of materials applications. In the last few years, several supercritical fluids-based techniques have been proposed for the production of micronic and nanometric particles for potential applications in areas such as pharmaceuticals, cosmetics, inorganics, biomaterials and explosives. Techniques like the rapid expansion of supercritical solutions (RESS), supercritical antisolvent precipitation (SAS), particle generation from gas-saturated solutions (PGSS), and reactive precipitation in supercritical solutions (RPSS) have been critically reviewed.
[References]
  1. Krukonis V, "Supercritical Fluid Nucleation of Difficult to Comminute Solids," the AIChE Annual Meeting, San Francisco, 1984
  2. Subramaniam B, Rajewski RA, Snavely K, J. Pharm. Sci., 86(8), 885, 1997
  3. Hanney JB, Hogarht J, Proc. Roy. Soc., 29, 324, 1879
  4. Jung J, Perrut M, J. Supercrit. Fluids, 20, 179, 2001
  5. Gallagher PM, Krukonis VJ, Botsaris GD, AIChE Symp. Ser., 82(284), 96, 1989
  6. Yeo S, Debenedetti PG, Radosz M, Schmidt H, Macromolecules, 26, 6207, 1993
  7. Benedetti L, Bertucco A, Pallado P, Biotechnol. Bioeng., 53(2), 232, 1997
  8. Randolph TW, Randolph AJ, Mebes M, Yeung S, Biotechnol. Prog., 9, 429, 1993
  9. Kajimoto O, Chem. Rev., 99(2), 355, 1999
  10. Tucker SC, Chem. Rev., 99(2), 391, 1999
  11. Johannsen M, Brunner G, J. Chem. Eng. Data, 42(1), 106, 1997
  12. Chrastil J, J. Phys. Chem., 86, 3016, 1982
  13. McHugh MA, Krukonis VJ, Supercritical Fluid Extraction: Pronciples and Practice, 2nd ed., Butterworth-Heinemann, Boston, MA, 1994
  14. Mohamed RS, Halverson DS, Debenedetti PG, Prud'homme RK, Johnston KP, Penninger JML, Supercritical Fluid Science and Technology, ACS Symposium Series 406, ACS, Washington D.C., 355-378, 1989
  15. Tom JW, Debenedetti PG, J. Aerosol Sci., 22(5), 555, 1991
  16. Turk M, J. Supercrit. Fluids, 15(1), 79, 1999
  17. Helfgen B, Turk M, Schaber M, J. Power Sources, 110, 22, 2000
  18. Chang CJ, Randolph AD, AIChE J., 35(11), 1876, 1989
  19. Smith RD, Wash R, "Supercritical Fluid Molecular Spray Film Deposition and Powder Formation," U.S. Patent, 4,582,731, 1986
  20. Perrut M, Jung J, Leboeuf F, French Patent, Application FR-02 05046, 2002
  21. Gallagher PM, Coffey MP, Krukonis VJ, Klasutis N, Johnston KP, Penninger JML, Supercritical Fluid Science and Technology, ACS Symposium Series 406, ACS, Washington D.C., 334-354, 1989
  22. Gallagher PM, Coffey MP, Krukonis VJ, Hillstrom WW, J. Supercrit. Fluids, 5, 130, 1992
  23. Gallagher MP, Krukonis VJ, Coffey MP, "Gas Anti-Solvent Recrystallization and Application for the Separation and Subsequent Processing of RDX and HMX," U.S. Patent, 5,389,263, 1992
  24. Dixon DJ, Johnston KP, AIChE J., 37(10), 1441, 1991
  25. Dixon DJ, Lunabarcenas G, Johnston KP, Polymer, 35(18), 3998, 1994
  26. Bodmeier R, Wang H, Dixon DJ, Mawson S, Johnston KP, Pharm. Res., 12(8), 1211, 1994
  27. Yeo SD, Lim BG, Debenedetti PG, Bernstein H, Biotechnol. Bioeng., 41, 341, 1993
  28. Schmitt WJ, Salada MC, Shook GG, Speaker SM, AIChE J., 41(11), 2476, 1995
  29. Chou YH, Tomasko DL, "GAS Crystallization of Polymer-pharmaceutical Composite Particles," The 4th International Symposium on Supercritical Fluids, May, Sendai, Japan, 1997
  30. Reverchon E, DellaPorta G, DiTrolio A, "Morphological Analysis of Nanoparticles Generated by SAS," Fourth Italian Conference on Supercritical Fluids and Their Applications, September, Capri, 1997
  31. Reverchon E, DellaPorta G, Celano C, Pace S, DiTrolio A, J. Mater. Res., 13(2), 284, 1998
  32. Amaro-Gonzalez D, Mabe G, Zabaloy M, Brignole EA, J. Supercrit. Fluids, 17(3), 249, 2000
  33. Chattopadhyay P, Gupta RB, "Supercritical CO2 Based Production of Fullerene Nanoparticles," the 5th International Symposium on Supercritical Fluids, April, Atlanta, 2000
  34. Hong L, Bitemo SR, Gao Y, Yuan WK, "Precipitation of Microparticulate Organic Pigment Powders by Supercritical Antisolvent (SAS) Process," the 5th International Symposium on Supercritical Fluids, April, Atlanta, 2000
  35. Reverchon E, DeMarco I, DellaPorta G, J. Supercrit. Fluids, 23(1), 81, 2002
  36. Thiering R, Dehghani F, Foster NR, J. Supercrit. Fluids, 21(2), 159, 2001
  37. Hanna M, York P, "Method and Apparatus for the Formation of Particles," WO 95/01221, 1994
  38. Hanna M, York P, "Method and Apparatus for the Formation of Particles," WO 96/00610, 1995
  39. Hanna M, York P, "Method and Apparatus for the Formation of Particles," WO 98/36825, 1998
  40. Bustami RT, Chan HK, Dehghani F, Foster NR, "Generation of Protein Micro-Particles using High Pressure Modified Carbon Dioxide," the 5th International Symposium on Supercritical Fluids, April, Atlanta, 2000
  41. Novak Z, Senvar-Bozic P, Rizner A, Knez Z, "Particles from Gas Saturated Solution - PGSS," Fluidi Supercriticie Le Loro Applicazioni. E. Reverchon, A. Schiraldi (Eds.), June, Ravello, 1993
  42. Prince WD, Keller GE, Fraser WA, Leung PS, "Spray Application of Plastic Additives to Polymers," EP 590647, 1993
  43. Sievers RE, Karst U, "Methods and Apparatus for Fine Particle Formation," EP 0677332, 1995
  44. Weidner E, Steiner R, Knez Z, "Powder Generation from Polyethyleneglycols with Compressible Fluids," the 3rd Int. Sym. on High Pressure Chemical Engineering, October, Zurich, 1996
  45. Sievers RE, Karst U, Milewski PD, Sellers SP, Miles BA, Schaefer JD, Stoldt CR, Xu CY, Aerosol Sci. Technol., 30, 3, 1999
  46. Sievers RE, Milewski PD, Sellers SP, Miles BA, Korte BJ, Kusek KD, Clark GS, Mioskowski B, Villa JA, "Supercritical and Near-Critical Carbon Dioxide Assisted Low Temperature Bubble Drying," The 5th International Symposium on Supercritical Fluids, April, Atlanta, 2000
  47. Ventosa N, Veciana J, Rovira C, Sala S, "Method for Precipitating Finely Divided Solid Particles," WO 02/16003, 2002
  48. Ventosa N, Sala S, Veciana J, Torres J, Llivre J, "Depressurization of an Expanded Liquid Organic Solution (DELOS): A New Procedure for Obtaining Submicron- or Micron-Sized Crystalline Particles," Crystal Growth and Design, 1, 299-303, 2001
  49. Hakuta Y, Adschiri T, Suzuki T, Chida T, Seino K, Arai K, J. Am. Ceram. Soc., 81(9), 2461, 1998
  50. Hakuta Y, Onai S, Terayama H, Adschiri T, Arai K, J. Mater. Sci. Lett., 17(14), 1211, 1998
  51. Lee YW, Theor. Appl. Chem. Eng., 7(1), 705, 2001
  52. Prober CG, Walson D, Jones J, Pediatrics, 106(6), 89, 2000