The motion and deformation of contaminated bubbles driven by a surrounding liquid in a horizontal Hele-Shaw cell has been studied. For the effective analysis of interfacial deformation, immiscible water-silicone oil system was adopted as a two-phase flow environment. The effects of interfacial contamination on the motion and deformation of water bubble were investigated with the variation of the controlled quantity of surfactants. For the small basic flow of silicone oil, the shapes of bubble were formed as a circle or a ellipse. As the magnitude of basic flow was increased, the shape of deforming interface was elongated along the flow direction. And the elongated bubbles moved faster than the basic flow, the elongated bubble transformed itself into sharp-tailed bubble with round-front cap. And the length of elongated bubble with sharp tail was shorten with increasing the concentration of surface-active contaminants up to the critical micelle concentration. It is considered that these observations may be due to the influence of surface-active contaminants. The present study suggests that the Marangoni effect due to the different interfacial tension along the interface makes the shape of water bubble in a silicone oil unstable.