The effects of rotational speed, impeller diameter, the angle of impeller tip and the pitched angle of impeller tip on the energy dissipation rate per unit volume(P/V) were investigated in the autoclave of 0.28㎥ with stirring unit. The energy dissipation rate per unit volume increased with increasing rotational speed, impeller diameter, the angle of impeller tip and the pitched angle of impeller tip. The mean particle diameter of PVC resin decreased with increasing the energy dissipation rate per unit volume, and the coefficient variance(CV) of PVC resin exhibited a minimum value at the energy dissipation rate per unit volume between 0.9 and 1.0kW/㎥. The energy dissipation rate per unit volume was correlated to the operating variables on the stirred tank. The dimensionless correlation equation of Reynolds number for the mean particle diameter of PVC was also presented based on the isotropic turbulent theory.