We have studied experimentally and theoretically the desorption characteristics of wool grease on the wool with supercritical carbon dioxide, contiaining 0.6-4.4mole% of cosolvent, at the pressures up to 35MPa, the temperature of 313.2K, 323.2K and 333.2K and constant flow rate of solvent. Desorption rates of wool grease are found to increase with the concentration increase of cosolvent, to decrease generally with the temperature increase and to increase markedly with increasing pressure. The final desorption amounts are nearly constant at a specified condition. Benzene is proved to be a better cosolvent than n-hexane or methylacetate of the same concentrations in above desorption experiments. The desorption rate constants in the model, k₁ is nearly constant at constant pressure and concentration of cosolvent, k₂ increases with the increase of desorption amount. HPLC chromatograms of the wool grease desorbed show that compositions of the desorpted wool grease are varied with various desorption conditions.