The desorption characteristics of wool grease on wool with supercritical carbon dioxide were studied experimentally and theoretically at the pressure up to 35MPa, the temperature range of 313.2-333.2K and constant flow rate of carbon dioxide. desorption rates of wool grease were found to increase markedly with increasing pressure, to decrease generally with increasing temperature and to increase with increasing flow rate but the final desorption amounts were constant. The highest desorption amount of wool grease was 80% at the temperature of 313.2K and the pressure of 35MPa with the flow rate of carbon dioxiide of 440ml(STP)/ min, but desirable desorption amount(95-96%) was not found at the experimental condition. The experimental data were well correlated to desorption rate model, that was proposed by appling the material balance in fixed bed. The desorption rate constants in the model, k₁ was nearly constant at constant pressure and k₂ was increased with increasing desorption rate.