Vapor-liquid equilibrium data were obtained for the ethanol-water system with glucose at atmos-pheric pressure. Ethanol enriched vapor phase was obtained by adding glucose to ethanol-water system. The degree of enrichment increases with the increase in the glucose concentration. The equation correlating the activity coefficient and ethanol concentration in the liquid phase adequately represents the equilibrium behavior. In the conventional distillation column, the theoretical number of plate and cost of distillation de-crease with the iincrease in the glucose concentration. This result can be used to develop an ethanol fermenta-tion-distillation process aiming for high productiivity and low energy consumption.