The automatic synthesis of operating procedures for chemical plants improves plant safety and reduces design costs. However, the existing operating procedure synthesis techniques have limitations in simulating a change of process states by the operation and selecting operations and subgoals needed to achieve the operational goal. So in this study, we have proposed the integrated framework based on constraint propagation to resolve problems about operation selection due to subgoal interaction among subgoals and to effectively use the process knowledge. The proposed methodology has been successfully applied to the process with serious subgoal interaction.