A properly chosen suboptimal policy for catalyst distribution in a two-enzyme packed bed reactor is sometimes better than optimal policy itself in actual cases. This often occurs when optimal policy is only theoretically possible and experimentally infeasible. Immobilized glucoamylase （=G. A.） with optimum pH 4.5 and immobilized glucose isomerase (=G. I.) with optimum pH 7.0 cannot be mixed without sacrificing the activities and the stabilities of two immobilized enzymes. However utilizing suboptimal policies such as bang-bang policy (maximization of product) and bang-bang-bang policy (minimization of reactant) would permit two immobilized enzymes in separate reactors where optimum environments for G. A. and G. I. could be provided. The partial experimental investigation of the above suboptimal policies was conducted using immobilized G. A. and immobilized G. I. at the temperature of 40 ℃ and pH 6.5 where no appreciable decay in the activities of both enzymes could take place. The simulated results of suboptimal policies in a reactor undergoing decay of enzyme activity showed that the predicted conversions using bang-bang policy were comparable to the theoretical conversions of the optimal bed policy and it should be one of the best policy for the maximum production of fructose syrup in practice.