Until a recent day, degradation of PEMFC MEA (membrane and electrode assembly) has been studied, separated with membrane degradation and electrode degradation, respectively. But membrane and electrode were degraded coincidentally at real PEMFC operation condition. During simultaneous degradation, there was interaction between membrane degradation and electrode degradation. The effect of electrode degradation on membrane degradation was studied in this work. We compared membrane degradation after electrode degradation and membrane degradation without electrode degradation. I-V performance, hydrogen crossover current, fluoride emission rate (FER), impedance and TEM were measured after and before degradation of MEA. Electrode degradation reduced active area of Pt catalyst, and then radical/H2O2 evolution rate decreased on Pt. Decrease of radical/H2O2 reduced the velocity of membrane degradation.